Hyoscyamine, Atropine, Scopolamine, and Phenobarbital



Donnatal®; Donnatal Extentabs®







Hyoscyamine, Atropine, Scopolamine, and Phenobarbital

(hye oh SYE a meen, A troe peen, skoe POL a meen & fee noe BAR bi tal)

U.S. Brand Names
Donnatal®; Donnatal Extentabs®
Pharmacologic Category
Anticholinergic Agent; Antispasmodic Agent, Gastrointestinal
Reasons not to take this medicine
  • If you have an allergy to hyoscyamine, atropine, scopolamine, phenobarbital, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you have any of the following conditions: Bleeding problems, fast heartbeat, glaucoma, intestinal blockage, myasthenia gravis, slow-moving gastrointestinal tract, porphyria, ulcerative colitis, or urinary tract blockage.
What is this medicine used for?
  • This medicine is used to slow the speed through the stomach and gastrointestinal tract.
  • This medicine is used to treat irritable bowel syndrome.
  • This medicine is used to treat muscle spasms of the gastrointestinal tract, gallbladder system, or urinary system.
How does it work?
  • Hyoscyamine, atropine, and scopolamine slows movement through the gastrointestinal tract and urinary tract.
  • Phenobarbital calms the brain.
How is it best taken?
  • Take this medicine with or without food. Take with food if it causes an upset stomach.
  • Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by healthcare provider.
  • Long-acting products: Swallow whole. Do not chew, break, or crush.
  • A liquid (elixir) is available if you cannot swallow pills.
  • Those who have feeding tubes can also use the liquid. Flush the feeding tube before and after medicine is given.
  • If you are taking this medicine for irritable bowel syndrome or spasms of the gastrointestinal tract, take 30-60 minutes before meals.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take a double dose or extra doses.
  • Do not change dose or stop medicine. Talk with healthcare provider.
What are the precautions when taking this medicine?
  • If you are 65 or older, use this medicine with caution. You could have more side effects.
  • If you are a male with problems urinating, talk with healthcare provider.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
  • Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions. These include sedatives, tranquilizers, mood stabilizers, antihistamines, and other pain medicine.
  • You can get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen; wear protective clothing and eyewear.
  • Be careful in hot weather. Drink plenty of fluids to prevent dehydration.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
  • Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
  • Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
  • Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.
  • Follow up with healthcare provider.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Severe dizziness or passing out.
  • Significant change in thinking clearly and logically.
  • Unable to pass urine.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect capsules and tablets from moisture. Do not store in a bathroom or kitchen.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
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