Guaifenesin and Phenylephrine



Aldex™; Amidal; Ami-Tex LA; Crantex ER; Crantex LA; Deconsal® II; Endal®; Entex®; Entex® ER; Entex® LA; Guaifed®; Guaifed-PD®; Liquibid-D; Liquibid-PD; PhenaVent™; PhenaVent™ D; PhenaVent™ Ped; Prolex™-D; Rescon GG; Sil-Tex; Sina-12X; SINUvent® PE







Guaifenesin and Phenylephrine

(gwye FEN e sin & fen il EF rin)

U.S. Brand Names
Aldex™; Amidal; Ami-Tex LA; Crantex ER; Crantex LA; Deconsal® II; Endal®; Entex®; Entex® ER; Entex® LA; Guaifed®; Guaifed-PD®; Liquibid-D; Liquibid-PD; PhenaVent™; PhenaVent™ D; PhenaVent™ Ped; Prolex™-D; Rescon GG; Sil-Tex; Sina-12X; SINUvent® PE
Pharmacologic Category
Decongestant; Expectorant
Reasons not to take this medicine
  • If you have an allergy to guaifenesin, phenylephrine, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you have any of the following conditions: Fast heartbeat or uncontrolled high blood pressure.
  • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.
What is this medicine used for?
  • This medicine is used to thin secretions.
  • This medicine is used to treat nasal congestion.
How does it work?
  • Guaifenesin thins fluids in the lungs.
  • Phenylephrine shrinks swollen nasal tissue and opens up passages.
How is it best taken?
  • Take this medicine with a full glass of water.
  • Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by healthcare provider.
  • Long-acting products: Swallow whole. Do not chew, break, or crush.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take a double dose or extra doses.
  • Many times this medicine is taken on an as needed basis.
What are the precautions when taking this medicine?
  • This medicine is not for coughs due to smoking or lung disease.
  • If you have diabetes, talk with healthcare provider.
  • If you have glaucoma, talk with healthcare provider.
  • If you have heart disease, talk with healthcare provider.
  • If you have high blood pressure, talk with healthcare provider.
  • If you have thyroid disease, talk with healthcare provider.
  • If you are a male with problems urinating, talk with healthcare provider.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Limit caffeine (for example, tea, coffee, cola) and chocolate intake. Use with this medicine may cause nervousness, shakiness, and fast heartbeat.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
  • Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
  • Headache.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Take good care of your teeth. See a dentist regularly.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Severe headache.
  • Persistent cough.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect from light.
  • Protect from moisture. Do not store in a bathroom or kitchen.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
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