Primaquine Phosphate









Primaquine Phosphate

(PRIM a kween FOS fate)

Pharmacologic Category
Aminoquinoline (Antimalarial)
Reasons not to take this medicine
  • If you have an allergy to primaquine or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
What is this medicine used for?
  • This medicine is used to prevent or treat malaria.
  • This medicine is used to treat Pneumocystis carinii pneumonia.
How does it work?
  • Primaquine works to injure the parasite and fight the infection.
How is it best taken?
  • To gain the most benefit, do not miss doses.
  • Use prescription as directed, even if feeling better.
  • Take with food.
  • This medicine should be started before travel to the high risk area. Continue use after leaving the area.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take a double dose or extra doses.
What are the precautions when taking this medicine?
  • Be careful if you have G6PD deficiency. Anemia may occur.
  • If you have bone marrow disease, talk with healthcare provider.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Avoid alcohol (includes wine, beer, and liquor).
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
  • Malaria:
  • Other protective measures are needed along with this medicine including using screens, bednetting, insect repellent (10% to 35% DEET), and permethrin spray on clothing and nets. Avoid spraying most insect repellents on children. Decrease evening and night-time outdoor activity.
  • Pregnant females traveling to malaria infested areas should discuss the risks with a healthcare provider first.
What are some possible side effects of this medicine?
  • Anemia.
  • Belly pain.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Take good care of your teeth. See a dentist regularly.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Difficulty breathing.
  • Fever that occurs while in or after return from the malaria area.
  • Severe nausea or vomiting.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect from moisture. Do not store in a bathroom or kitchen.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
Brand Names: