Lidocaine and Epinephrine



LidoSite™; Xylocaine® MPF With Epinephrine; Xylocaine® With Epinephrine







Lidocaine and Epinephrine

(LYE doe kane & ep i NEF rin)

U.S. Brand Names
LidoSite™; Xylocaine® MPF With Epinephrine; Xylocaine® With Epinephrine
Canadian Brand Names
Xylocaine® With Epinephrine
Pharmacologic Category
Local Anesthetic
Reasons not to take this medicine
  • If you have an allergy to lidocaine, epinephrine, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • Injection:
  • If you have any of the following conditions: Glaucoma, myasthenia gravis, shock, or slow heartbeat without a working pacemaker.
  • Skin Patch:
  • If you have a defibrillator or pacemaker.
What is this medicine used for?
  • This medicine is used to numb an area of the skin before a procedure.
How does it work?
  • Lidocaine numbs the nerves in the area applied.
  • Epinephrine lengthens the effect of lidocaine.
How is it best taken?
  • All forms:
  • Your healthcare provider will give this medicine.
  • Injection:
  • This medicine is given as a shot into the skin.
  • Skin patch:
  • This medicine is applied to the skin.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Many times this medicine is taken on an as needed basis.
What are the precautions when taking this medicine?
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Do not eat while your mouth feels numb. You may injure yourself by biting your tongue.
  • If you have a sulfite allergy, talk with healthcare provider.
  • If you have liver disease, talk with healthcare provider.
  • If you have thyroid disease, talk with healthcare provider.
  • If you have a weakened heart, talk with healthcare provider.
  • Avoid grapefruit and grapefruit juice.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
  • Injection:
  • Irritation where the shot is given.
  • Skin patch:
  • Skin irritation.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Significant change in balance.
  • Sudden change in vision, eye pain or irritation.
  • Weakness, numbness, or tingling.
  • Severe skin irritation.
  • Significant change in thinking clearly and logically.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • This medicine will be given to you in a healthcare setting. You will not store it at home.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
Brand Names: