Muromonab-CD3



Orthoclone OKT® 3







Muromonab-CD3

(myoo roe MOE nab see dee three)

U.S. Brand Names
Orthoclone OKT® 3
Canadian Brand Names
Orthoclone OKT® 3
Mexican Brand Names
Orthoclone®
Pharmacologic Category
Immunosuppressant Agent
What key warnings should I know about before taking this medicine?
  • Some patients experience severe reactions during the infusion.
Reasons not to take this medicine
  • If you have an allergy to muromonab or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you are allergic to mouse proteins, talk with healthcare provider.
  • If you have any of the following conditions: Seizures, water in the lungs, or uncontrolled high blood pressure.
  • If you are pregnant or may be pregnant.
  • If you are breast-feeding.
What is this medicine used for?
  • This medicine is used to prevent rejection after organ transplant.
How does it work?
  • Muromonab-CD3 helps the body accept a transplanted organ.
  • It decreases the body's harmful response to diseases affecting the immune system.
How is it best taken?
  • This medicine is given as a shot into a vein.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not change dose or stop medicine. Talk with healthcare provider.
What are the precautions when taking this medicine?
  • The risk of cancer is higher after taking this medicine.
  • Serious infections have been reported with use of this medicine. If you have any infection, are taking antibiotics now or in the recent past, or have many infections, talk with healthcare provider.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Be careful about taking vaccinations while you are receiving this medicine.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
  • Flu-like symptoms. These include headache, weakness, fever, shakes, aches, pains, and sweating. Mild pain medicine may help.
  • Diarrhea.
  • Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
  • Difficulty passing urine.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Check blood work regularly. Talk with healthcare provider.
  • Check weight weekly. Report a weight loss to healthcare provider.
  • For the occurrence of side effects.
  • Take good care of your teeth. See a dentist regularly.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
  • Difficulty breathing.
  • Fast heartbeat.
  • Significant change in thinking clearly and logically.
  • Severe headache.
  • Seizures.
  • Unable to pass urine.
  • Severe nausea or vomiting.
  • Severe diarrhea.
  • Swelling.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store in a refrigerator.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
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