Rosiglitazone and Glimepiride



Avandaryl™







Rosiglitazone and Glimepiride

(roh si GLI ta zone & GLYE me pye ride)

U.S. Brand Names
Avandaryl™
Pharmacologic Category
Antidiabetic Agent, Sulfonylurea; Antidiabetic Agent, Thiazolidinedione
Reasons not to take this medicine
  • If you have an allergy to glimepiride, rosiglitazone or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you have a sulfonamide (“sulfa”) allergy, talk with healthcare provider.
  • If you have any of the following conditions: Acidic blood condition or type 1 diabetes.
  • If you have active liver disease or yellowing skin or eyes during troglitazone therapy.
  • If you are breast-feeding.
What is this medicine used for?
  • This medicine is used to lower blood sugar in diabetic patients.
  • It may take 3 months to see the full effect.
How does it work?
  • Rosiglitazone increases insulin activity in the body.
  • Glimepiride increases insulin secretion from the pancreas and may make tissues more responsive to insulin.
How is it best taken?
  • Take this medicine with the first meal of the day.
  • Follow diet plan and exercise program as recommended by healthcare provider.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take a double dose or extra doses.
  • Do not change dose or stop medicine. Talk with healthcare provider.
What are the precautions when taking this medicine?
  • Wear disease medical alert identification.
  • If you are 80 or older, use this medicine with caution. You could be more sensitive to low blood sugar.
  • If you have high cholesterol, talk with healthcare provider.
  • If you have kidney disease, talk with healthcare provider.
  • If you have a weakened heart, talk with healthcare provider.
  • Do not drive if blood sugar has been low. There is a greater risk of an accident.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Avoid alcohol (includes wine, beer, and liquor).
  • Risk of pregnancy in females of childbearing age who have not been ovulating.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.
What are some possible side effects of this medicine?
  • Low blood sugar. Signs include anger, shaking, fast heartbeat, confusion, or sweating. Keep hard candies, liquid glucose, or milk on hand for low blood sugar.
  • High cholesterol level.
  • Headache.
  • Nasal irritation.
  • Cough.
  • Weight gain.
  • Swelling.
  • Liver damage can rarely occur.
  • Worsening of heart failure can rarely occur.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Check blood sugar as directed by healthcare provider.
  • Check blood work regularly. Talk with healthcare provider.
  • Have a yearly eye exam and visit to the foot doctor.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
  • Very low blood sugar or very high blood sugar.
  • Difficulty breathing.
  • Swelling of legs or belly.
  • Significant weight gain.
  • Severe nausea or vomiting.
  • Not hungry.
  • Dark urine or yellow skin or eyes.
  • Sudden change in vision or in the way you see color.
  • Feeling extremely tired or weak.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect from light.
  • Protect from moisture. Do not store in a bathroom or kitchen.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
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