Chlorpheniramine and Acetaminophen



Coricidin HBP® Cold and Flu [OTC]







Chlorpheniramine and Acetaminophen

(klor fen IR a meen & a seet a MIN oh fen)

U.S. Brand Names
Coricidin HBP® Cold and Flu [OTC]
Pharmacologic Category
Antihistamine/Analgesic
Reasons not to take this medicine
  • If you have an allergy to chlorpheniramine, acetaminophen, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you are breast-feeding.
What is this medicine used for?
  • This medicine is used to relieve allergy symptoms.
  • This medicine is used to relieve pain.
How does it work?
  • Chlorpheniramine blocks the allergic reaction by minimizing or preventing the body's reaction to the allergen.
  • Acetaminophen blocks production and release of chemicals that cause pain.
How is it best taken?
  • Do not take more than prescribed amount. Liver damage can occur.
  • This medicine is most effective if started before contact with the allergen. Take at least 1-3 hours before.
  • Take this medicine with or without food. Take with food if it causes an upset stomach.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take a double dose or extra doses.
  • Many times this medicine is taken on an as needed basis. Do not take more often than every 4 hours, unless instructed by healthcare provider.
What are the precautions when taking this medicine?
  • Wear disease medical alert identification.
  • Avoid other sources of acetaminophen. An overdose may cause dangerous problems.
  • If you have liver disease, talk with healthcare provider.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
  • Avoid medicines and natural products that slow your actions and reactions. These include sedatives, tranquilizers, mood stabilizers, antihistamines, and other pain medicine.
  • Avoid or limit alcohol intake (includes wine, beer, and liquor) to less than 3 drinks a day. Drinking too much alcohol may increase the risk of liver disease.
  • Be careful if you have G6PD deficiency. Anemia may occur.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
What are some possible side effects of this medicine?
  • Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
  • Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
  • Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
  • Liver damage can rarely occur.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Feeling extremely tired or weak.
  • Yellow skin or eyes.
  • Not hungry.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect from light.
  • Protect from moisture. Do not store in a bathroom or kitchen.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
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