Levodopa and Carbidopa



Parcopa™; Sinemet®; Sinemet® CR







Levodopa and Carbidopa

(lee voe DOE pa & kar bi DOE pa)

U.S. Brand Names
Parcopa™; Sinemet®; Sinemet® CR
Canadian Brand Names
Apo-Levocarb®; Apo-Levocarb® CR; Endo®-Levodopa/Carbidopa; Novo-Levocarbidopa; Nu-Levocarb; Sinemet®; Sinemet® CR
Pharmacologic Category
Anti-Parkinson's Agent, Dopamine Agonist
Reasons not to take this medicine
  • If you have an allergy to levodopa, carbidopa, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
  • If you have any of the following conditions: Glaucoma, melanoma, or unexplained skin spots.
  • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.
What is this medicine used for?
  • This medicine is used to treat Parkinson's disease.
  • This medicine is used to treat restless leg syndrome.
How does it work?
  • Levodopa and carbidopa improves the chemical balance in the brain.
How is it best taken?
  • Take this medicine with or without food. Take with food if it causes an upset stomach.
  • Avoid high protein diets.
  • Long-acting products: Swallow whole or as a half. Do not chew, break, or crush.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
  • Do not take long-acting products more often than every 6 hours, unless instructed by healthcare provider.
  • Do not take a double dose or extra doses.
  • Do not change dose or stop medicine. Talk with healthcare provider.
What are the precautions when taking this medicine?
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
  • Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions. These include sedatives, tranquilizers, mood stabilizers, antihistamines, and other pain medicine.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
  • Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
  • Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Check blood pressure and heart rate regularly.
  • Take good care of your teeth. See a dentist regularly.
  • Follow up with healthcare provider.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Significant change in balance.
  • Significant change in thinking clearly and logically.
  • Severe nausea or vomiting.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect from light.
  • Protect from moisture. Do not store in a bathroom or kitchen.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
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