Chlorophyllin, Papain, and Urea



Panafil®; Ziox™







Chlorophyllin, Papain, and Urea

(KLOR oh fil in, pa PAY in, & yoor EE a)

U.S. Brand Names
Panafil®; Ziox™
Pharmacologic Category
Enzyme, Topical Debridement
Reasons not to take this medicine
  • If you have an allergy to chlorophyllin, papain, urea, or any other part of this medicine.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
What is this medicine used for?
  • This medicine is used to promote healing of skin ulcers and wounds.
  • This medicine is used to decrease odor from wounds.
How does it work?
  • Chlorophyllin reduces swelling.
  • Papain and urea helps get rid of dead tissue.
How is it best taken?
  • Do not take this medicine by mouth. For skin only. Keep out of mouth, nose, and eyes (may burn).
  • Wash hands before and after use.
  • Clean affected area before use. Make sure to dry well.
  • Apply a thin layer to the affected skin.
  • Shake spray well before use.
  • Hold spray upright and about 2-3 inches from treatment area.
  • Spray and coat wound quickly.
What do I do if I miss a dose? (does not apply to patients in the hospital)
  • Apply a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
What are the precautions when taking this medicine?
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Tell healthcare provider if you are pregnant or plan on getting pregnant.
  • Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
  • Short-term discomfort after use.
What should I monitor?
  • Change in condition being treated. Is it better, worse, or about the same?
  • Follow up with healthcare provider.
Reasons to call healthcare provider immediately
  • If you suspect an overdose, call your local poison control center immediately or dial 911.
  • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
  • Severe skin irritation.
  • Any rash.
  • No improvement in condition or feeling worse.
How should I store this medicine?
  • Store at room temperature.
  • Protect spray from heat.
General statements
  • If you have a life-threatening allergy, wear allergy identification at all times.
  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
Brand Names: